Exploiting recent advances in material science, microfabrication, and cell biology and bringing together leading scientists and engineers from around the world, Nortis has developed a microfluidic chip technology (PAR-V), that is both functional and user-friendly. The PAR-V chip is a disposable microfluidic device made of PDMS and encased in a polycarbonate outer shell. Valve actuators and compression fittings have been elegantly integrated in the design to control perfusion through various flow-paths, which can be as small as 125 microns in diameter. This allows researchers to generate tiny segments of living human organs that can be perfused with nutrients, growth factors, and test compounds. Among other applications, the chip can be used to study barrier functions, cell-cell interactions and the effects of drugs and test compounds. Additionally, the PAR-V chip and supporting bioreactor hardware have been intellegnitly designed to retrofit standard lab equipment. This groundbreaking technology aims to provide powerful alternatives to the use of laboratory animals in the pharmaceutical industry.

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